Accuracy of Five Algorithms to Diagnose Gambiense Human African Trypanosomiasis
نویسندگان
چکیده
منابع مشابه
Accuracy of Five Algorithms to Diagnose Gambiense Human African Trypanosomiasis
BACKGROUND Algorithms to diagnose gambiense human African trypanosomiasis (HAT, sleeping sickness) are often complex due to the unsatisfactory sensitivity and/or specificity of available tests, and typically include a screening (serological), confirmation (parasitological) and staging component. There is insufficient evidence on the relative accuracy of these algorithms. This paper presents est...
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African trypanosomiasis caused by Trypanosoma brucei gambiense has not been reported in Italy. We report 2 cases diagnosed in the summer of 2004. Theses cases suggest an increased risk for expatriates working in trypanosomiasis-endemic countries. Travel medicine clinics should be increasingly aware of this potentially fatal disease.
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INTRODUCTION Human African Trypanosomiasis (HAT), or sleeping sickness, is a neglected tropical parasitic disease of humans due to trypanosomes transmitted by tsetse flies (Glossina spp.) in sub-Saharan Africa. Comparable diseases (Animal African Trypanosomiasis—AAT—nagana) are present in domesticated animals and these are an important constraint to animal health and production in Africa (Jorda...
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Treatment of second-stage gambiense human African trypanosomiasis relied on toxic arsenic-based derivatives for over 50 years. The availability and subsequent use of eflornithine, initially in monotherapy and more recently in combination with nifurtimox (NECT), has drastically improved the prognosis of treated patients. However, NECT logistic and nursing requirements remain obstacles to its dep...
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BACKGROUND Active screening by mobile teams is considered the best method for detecting human African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense but the current funding context in many post-conflict countries limits this approach. As an alternative, non-specialist health care workers (HCWs) in peripheral health facilities could be trained to identify potential cases who need t...
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ژورنال
عنوان ژورنال: PLoS Neglected Tropical Diseases
سال: 2011
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0001233